The stable wormhole discovered by the Deep Space Nine crew is known to the Bajoran people as the Celestial Temple of their Prophets. Sisko, as discoverer of the wormhole and its inhabitants, is therefore the Emissary of Bajoran prophesy. The wormhole's other end is in the Gamma Quadrant, halfway around the galaxy from Bajor. That section of space is dominated by the malevolent Dominion. The Dominion is led by the Changelings, the race of shapeshifters to which Odo belongs. As of the beginning of the sixth season, Cardassia has joined the Dominion, and together they are waging war on the Federation and their Klingon allies. The war is quickly becoming the most costly war ever for the Federation, and the Deep Space Nine crew must fight to protect their way of life.

Metcalfe will play a man who pretends to be crazy in order to save his sister (Sanchez) from being involuntarily hospitalized. Once inside the institute, the siblings discover that a doctor (Stormare) is using his patients like lab rats, forcing them to take a drug that turns them into flesh-eating psychopaths.

Once the ruler of an entire universe, the Great Spirit Mata Nui finds himself cast out of his own body, his spirit trapped inside the fabled Mask of Life, hurtling through space. After landing on the far-away planet of Bara Magna, the mask creates a new body for Mata Nui, who unwillingly gets caught up in the furious battles of the nearly barren and dangerous planet. The locals, called Agori ask for his help against the unrelenting army of the Rock Tribe, called the Skrall and their leader, Tuma. The Glatorian warriors start to train him, teach him how to protect himself, while Mata Nui also adds some of his special powers to their fighting skill. The experienced veteran Ackar, the feisty female Kiina, the young Glatorian Gresh, and a friendly, special beetle named Click aid him on his way. But there is a traitor among the Agori, and bigger secrets lay hidden under the sands of the desert planet...